Research and Studies

Randomized Controlled trial on 21 puppies using Sildenafil suggests the drug reduces the LES tone and facilitating the emptying of the esophagus, could represent a useful drug for the clinical management of Congenital Idiopathic Megaesophagus in Dogs. Veterinary Record (2017) F. Quintavalla, A. Menozzi, C. Pozzoli, E. Poli, P. Donati, D.K. Wyler, P. Serventi, S. Bertini

>>>Full Story Here<<<


The Veterinary Health Center (VHC) at the University of Missouri's College of Veterinary Medicine have identified an"LES-achalasia-like syndrome" in some dogs with idiopathic megaesophagus and have come up with a treatment plan: 


YOU and YOUR DOG can help make Megaesophagus HISTORY!


International Canine Megaesophagus Awareness



Join us in celebrating the growing awareness of Canine Megaesophagus around the world!  

Pet parents and vets alike are sharing their knowledge, treatment tips, stories, and support every day!  

Thank you! Thank you!  

Let's keep going!!

Leave no dog behind!!  

Megaesophagus is NOT a death sentence!!




University of California -San Diego
looking for samples for genetic study of canine Myasthenia Gravis
Study of Megaesophagus in Great Danes - Clemson University
Contact Leigh Anne Clark, Ph.D.
Mississippi State Veterinary School is conducting a study on the effects of Upright Feeding and dogs with idiopathic Megaesophagus.
Please contact Alison Khoo, Small Animal Internal Medicine/Surgery Intern at: to participate in this program.

Washington State University is offering Individualized esophageal motility imaging.

Please contact Jillian Haines DVM at to schedule an appointment.

Washington State University


ME Crisis in Latvia

There has been an unusually high number of megaesophagus cases reported in Latvia. Click here to learn more about the study currently being conducted.

This is the survey that veterinary clinics and hospitals are asked to complete to aid in the study findings

Hunger Pains
 Swallowing Disorders in Dogs (Dysphagia) An extremely well done video from UC Davis and Dr. Stanley Marks,BVS.c, Ph.D


Video Fluoroscopy
Minature Dachshund with megaesophagus, Minette, undergoing video fluoroscopy at Mississippi State University.


This is the imaging product of the Megaesophagus swallow test that both Kya and Weston had today.This is an extremely rare opportunity for you to see the internal view of what Megaesophagus is:Narrated by Dr.Jillian HainesPatient is Rescue4All foster puppy, KyaPlease like & share if you can!

Posted by Rescue4All on Thursday, October 6, 2016
This is Kyla undergoing Video Fluoroscopy while eating in her bailey chair. Study done at Washington State University Veterinary School by Dr. Jillian Haines

43 thoughts on “Research and Studies

  1. my pup has a vascular ring , scheduled CT scan for tues to see the condition of vessels then possibly surgery, any current info on recovery?

    1. Hi Margaret,
      I did a lot of research of PRAA when I wrote the article. There is a 90% success rate with the operation. We have spoken with a lot of pet parents that have had the surgery. Some have done very well after the surgery, eventually moving to regular eating from a bowl on the floor or slightly elevated. With other dogs the ME remains but is much more manageable. Your pup should be kept at the surgery center for a couple of days until the drain comes out. They can give your pup pain medicine through an IV and keep her hydrated. You will need to keep her quiet at home until she heals. Some say that’s the hardest part. Best of luck!

  2. I have two mega pups. One is a year old and one is five months. Same sire and dam. Yes, I know, stupid me , I did a repeat breeding. I really did not think it was hereditary. The other puppies are stunnng. So any way, I am feeding these two in bailey chairs. The eat raw, I’ve always fed raw. They are doing great. No AP yet. Keep your fingers crossed..I have the site and dam, ( both fixed now). I wanted to know if there’s a study needing DNA from all four?

    1. Hi Leslie,
      Yes there is strong evidence that this disease is hereditary. Right now Dr. Clark from Clemson University is studying Great Danes for the purpose of isolating and identifying the gene. Thank you for wanting to be part of the solution. Here is an article detailing the study. You can find Dr. Clark’s email in the center of the article FYI your other puppies in the litter should also be neutered. This is thought to be a recessive gene. Thank you for your comment!

  3. What would be the best place to contact to find out if any research is being done on a certain antibiotic being. A possible cause of Megaesophagus?

  4. Hello, I am fostering a puppy that was diagnosed with ME a few weeks ago. She has been doing great since her diagnosis with eating on the floor and then sitting in her backpack with zero regurgitation for a month. The last two days however she has regurgitated several times especially in the evenings. Should i keep her vertical longer in the evenings? I am not sure why this is happening since her other two meals she does not regurgitate at all and for a month she was completely okay.

    1. Hi Shannon,
      Sometimes things that have worked for awhile, stop working and you have to switch it up. I would definitely keep her vertical longer in the evenings to see if that helps. Some dogs do better if you feed before 7pm at night. Also, be sure to have her head elevated at night by using either a neck hug or pro collar. Keep a journal of what works and what doesn’t. Sometimes you can notice a pattern. Best of luck Shannon!

  5. I want to echo the use of neck hugs at night. We use the neck hug for our lab with ME and it has been a miracle in supporting his head up to prevent vomiting at night.

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